The next day, Spears' visitation rights had been suspended at an emergency court listening to, and Federline was given sole physical and legal custody of their sons. In February 2006, photos surfaced of Spears driving along with her son, Sean, on her lap instead of in a automotive seat. In September 2006, she gave birth to her second son, Jayden James. In November 2002, Timberlake launched the tune "Cry Me a River" because the second single from his solo debut album. Spears' efficiency of the single at the 2001 MTV Video Music Awards featured a caged tiger (wrangled by Bhagavan Antle) and a large albino python draped over her shoulders. In the Zone bought over 609,000 copies within the United States throughout its first week of availability in the United States, debuting at the top of the charts, making Spears the first female artist within the SoundScan period to have her first four studio albums to debut at number one. Crossroads, which had a $12 million funds, went on to gross over $61.1 million worldwide. Shortly after, she released her first perfume, Curious, with Elizabeth Arden, which broke the company's first-week gross for a perfume.

She was released five days later. In the United States, it was Spears' first album not to debut at number one, though, she did change into the only female artist to have her first 5 studio albums debut at the two prime slots of the chart. The second single "Piece of Me" reached the highest of the charts in Ireland and reached the top 5 in Australia, Canada, Denmark, New Zealand, and the United Kingdom. It also debuted at the top of the charts in France and the highest ten in Belgium, Denmark, Sweden, and the Netherlands. The track debuted at number two on the US Billboard Hot 100, selling a complete of 521,000 digital models, the second-highest-ever debut digital sales week. The album debuted atop the charts in Canada and Ireland, at number two within the U.S. There's two types of guys out there-those that hold your hand, and those that fuck you. She was dedicated to the psychiatric ward of Ronald Reagan UCLA Medical Center and put on 5150 involuntary psychiatric hold below California state regulation. Their divorce was finalized in July 2007, when the 2 reached a world settlement and agreed to share joint custody of their sons.

In November 2006, Spears filed for divorce from Federline, citing irreconcilable differences. In December 2007, Spears began a relationship with paparazzo Adnan Ghalib. Drunk History is a comedy series on Comedy Central that was launched on Funny or Die in December 2007. The present originated as a web sequence created by Derek Waters and Jeremy Konner. Blender cited it as one of the 25 sexiest music moments on tv historical past. A music online gay video chat directed by Colin Tilley was shot in October 2016, and in accordance with Spears, has an Eyes Wide Shut (1999) theme. In August 2003, Spears opened the MTV Video Music Awards with Christina Aguilera, performing "Like a Virgin". Spears performed the lead single "Gimme More" at the 2007 MTV Video Music Awards. In June 2002, Spears opened her first restaurant, Nyla, in New York City, however terminated her relationship in November, citing mismanagement and "management's failure to maintain her fully apprised".

Her profession success was highlighted by Forbes in 2002, as Spears was ranked the world's most powerful movie star. In January 2008, Spears refused to relinquish custody of her sons to Federline's representatives. In January 2004, Spears married her childhood pal Jason Allen Alexander at A bit of White Wedding Chapel in Las Vegas, Nevada. Minard, Katie (January 11, 2016). "Every episode of Lizzie McGuire, ranked". In February, Spears stayed in a drug rehabilitation facility in Antigua for lower than a day. She underwent arthroscopic surgical procedure and wore a thigh brace for six weeks, adopted by eight to twelve weeks of rehabilitation. They held a wedding ceremony ceremony on September 18, 2004, however were not legally married until three weeks later on October 6 on account of a delay finalizing the couple's prenuptial agreement. She admitted herself to other treatment facilities during the following weeks. Though in 2022, she later admitted to partaking in an affair with Robson. Spears had initially denied the allegations of a attainable affair involving Durst, despite the 2 being noticed collectively on a number of events; even claiming the two had a friendly connection. Spears' relationship with Justin Timberlake ended after three years.